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Spermatogenesis Volume 1, 2011 - Issue 4
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Review

Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility

Georges Pointis INSERM, U 895; University Sophia Antipolis; Nice, FranceCorrespondence[email protected]
,
Jérome Gilleron INSERM, U 895; University Sophia Antipolis; Nice, France
,
Diane Carette INSERM, U 895; University Sophia Antipolis; Nice, France; UMR S775; University Paris Descartes; Paris, France
&
Dominique Segretain UMR S775; University Paris Descartes; Paris, France
Pages 303-317 | Received 02 Sep 2011, Accepted 10 Oct 2011, Published online: 01 Dec 2011

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Ying Gao, Dolores D Mruk & C Yan Cheng. (2015) Sertoli cells are the target of environmental toxicants in the testis – a mechanistic and therapeutic insight. Expert Opinion on Therapeutic Targets 19:8, pages 1073-1090.
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C Yan Cheng. (2014) Toxicants target cell junctions in the testis: Insights from the indazole-carboxylic acid model. Spermatogenesis 4:2.
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HT Wan, Dolores D Mruk, Chris KC Wong & C Yan Cheng. (2013) Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals. Expert Opinion on Therapeutic Targets 17:7, pages 839-855.
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Articles from other publishers (52)

Hanna Hüneke, Marion Langeheine, Kristina Rode, Klaus Jung, Adrian Pilatz, Daniela Fietz, Sabine Kliesch & Ralph Brehm. (2023) Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells. Differentiation 134, pages 31-51.
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Ana Priscila Gomes-Silva, Paloma da Cunha de Medeiros, Laís Nogueira Silva, Marcella Da Silva Araújo Santiago & Juliana Elaine Perobelli. (2023) Exposure to manganese during sertoli cell formation and proliferation disturbs early testicular development in rats. Reproductive Toxicology 120, pages 108447.
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Sheila I. Peña‐Corona, Dinorah Vargas‐Estrada, Ivan Juárez‐Rodríguez, Socorro Retana‐Márquez & C. Adriana Mendoza‐Rodríguez. (2023) Bisphenols as promoters of the dysregulation of cellular junction proteins of the blood‐testis barrier in experimental animals: A systematic review of the literature. Journal of Biochemical and Molecular Toxicology 37:9.
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Zongxin Zhang, Xingde Du, Shiyu Zhang, Haohao Liu, Yu Fu, Fufang Wang & Huizhen Zhang. (2023) Adverse effects of microcystins on sperm: A systematic review. Toxicology 490, pages 153507.
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Olivia E Smith, Fanny Morin, Vickie Roussel, Micka C Bertucci, Alexandre Boyer & Bruce D Murphy. (2023) The role of steroidogenic factor 1 (SF-1) in steroidogenic cell function of the testes and ovaries of mature mice. Reproduction 165:1, pages 1-17.
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Affiefa Yawer, Eliška Sychrová, Jan Raška, Pavel Babica & Iva Sovadinová. (2022) Endocrine-disrupting chemicals affect Sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro. Food and Chemical Toxicology 164, pages 113004.
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Elikanah Olusayo Adegoke, Md Saidur Rahman, Shereen Amjad, Won-Ki Pang, Do-Yeal Ryu, Yoo-Jin Park & Myung-Geol Pang. (2022) Bisphenol A damages testicular junctional proteins transgenerationally in mice. Environmental Pollution 302, pages 119067.
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Temidayo S. Omolaoye, Nour Jalaleddine, Walter D. Cardona Maya & Stefan S. du Plessis. (2022) Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?. Frontiers in Physiology 13.
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Sheila Irais Peña-Corona, Walker Sixto Vásquez Aguire, Dinorah Vargas, Ivan Juárez & C. Adriana Mendoza-Rodríguez. (2021) Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis. Reproductive Toxicology 103, pages 139-148.
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Woo Jin Kim, Bong Soo Kim, Hyun Jung Kim, Young Dan Cho, Hye Lim Shin, Hee In Yoon, Yun Sil Lee, Jeong-Hwa Baek, Kyung Mi Woo & Hyun-Mo Ryoo. (2020) Intratesticular Peptidyl Prolyl Isomerase 1 Protein Delivery Using Cationic Lipid-Coated Fibroin Nanoparticle Complexes Rescues Male Infertility in Mice. ACS Nano 14:10, pages 13217-13231.
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Affiefa Yawer, Eliška Sychrová, Petra Labohá, Jan Raška, Tomáš Jambor, Pavel Babica & Iva Sovadinová. (2020) Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells. Toxicology and Applied Pharmacology 404, pages 115177.
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Ifeoluwa O. Awogbindin, Isaac A. Adedara, Philip A. Adeniyi, Alberta E. Agedah, Bisola F. Oyetunde, Precious D. Olorunkalu, Emmanuel Ogbuewu, Inioluwa A. Akindoyeni, Yusuf E. Mustapha, Oluwatoyin G. Ezekiel & Ebenezer O. Farombi. (2020) Nigral and ventral tegmental area lesioning induces testicular and sperm morphological abnormalities in a rotenone model of Parkinson’s disease. Environmental Toxicology and Pharmacology 78, pages 103412.
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Erika Hilbold, Ottmar Distl, Martina Hoedemaker, Sandra Wilkening, Rüdiger Behr, Aleksandar Rajkovic, Marion Langeheine, Kristina Rode, Klaus Jung, Julia Metzger & Ralph H. J. Brehm. (2020) Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. Cells 9:3, pages 676.
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Dana Landschaft. (2020) Gaps and barriers: Gap junctions as a channel of communication between the soma and the germline. Seminars in Cell & Developmental Biology 97, pages 167-171.
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Julie W. Cheng & Edmund Y. Ko. 2020. Genetics of Male Infertility. Genetics of Male Infertility 57 71 .
Ya-Ping Jiang, Jia-Mei Yang, Rui-Juan Ye, Ning Liu, Wen-Jin Zhang, Lin Ma, Ping Zheng, Jian-Guo Niu, Ping Liu & Jian-Qiang Yu. (2019) Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways. Biomedicine & Pharmacotherapy 120, pages 109474.
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Anran Xu, Jianye Wang, Haiyu Wang, Yanqing Sun & Tianyu Hao. (2019) Protective effect of lycopene on testicular toxicity induced by Benzo[a]pyrene intake in rats. Toxicology 427, pages 152301.
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Yuan Zhou, Yu Chen, Xueqin Hu, Jun Guo, Hao Shi, Guang Yu & Zongxiang Tang. (2019) Icariin attenuate microcystin-LR-induced gap junction injury in Sertoli cells through suppression of Akt pathways. Environmental Pollution 251, pages 328-337.
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E. Hilbold, M. Bergmann, D. Fietz, S. Kliesch, W. Weidner, M. Langeheine, K. Rode & R. Brehm. (2019) Immunolocalization of DMRTB1 in human testis with normal and impaired spermatogenesis. Andrology 7:4, pages 428-440.
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Elikanah Olusayo Adegoke, Samson Olugbenga Adeniran, Yue Zeng, Xue Wang, Hao Wang, Chen Wang, Han Zhang, Peng Zheng & Guixue Zhang. (2019) Pharmacological inhibition of TLR4/NF‐κB with TLR4‐IN‐C34 attenuated microcystin‐leucine arginine toxicity in bovine Sertoli cells. Journal of Applied Toxicology 39:6, pages 832-843.
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Petra Kubincová, Eliška Sychrová, Jan Raška, Amrita Basu, Affiefa Yawer, Aneta Dydowiczová, Pavel Babica & Iva Sovadinová. (2019) Polycyclic Aromatic Hydrocarbons and Endocrine Disruption: Role of Testicular Gap Junctional Intercellular Communication and Connexins. Toxicological Sciences 169:1, pages 70-83.
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Silvina Beatriz Meroni, María Noel Galardo, Gustavo Rindone, Agostina Gorga, María Fernanda Riera & Selva Beatriz Cigorraga. (2019) Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation. Frontiers in Endocrinology 10.
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E.O. Adegoke, Wang Xue, N.S. Machebe, S.O. Adeniran, Wang Hao, Wang Chen, Zhang Han, Zhang Guixue & Zheng Peng. (2018) Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4/NF-kB and mitochondrial signaling pathways blockage. Ecotoxicology and Environmental Safety 166, pages 165-175.
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David Baruc Cruvinel Lima, Lúcia Daniel Machado da Silva & Pierre Comizzoli. (2018) Influence of warming and reanimation conditions on seminiferous tubule morphology, mitochondrial activity, and cell composition of vitrified testicular tissues in the domestic cat model. PLOS ONE 13:11, pages e0207317.
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Xiaoli Ji, Xin Chou, Zehe Ge, Fan Ding, Hui Gao & Qing Wu. (2018) Benzo[ a ]pyrene‐decreased gap junctional intercellular communication via calcium/calmodulin signaling increases apoptosis in TM4 cells . Journal of Applied Toxicology 38:8, pages 1091-1103.
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Qing Wen, Elizabeth I. Tang, Ying Gao, Tito T. Jesus, Darren S. Chu, Will M. Lee, Chris K.C. Wong, Yi-Xun Liu, Xiang Xiao, Bruno Silvestrini & C. Yan Cheng. (2018) Signaling pathways regulating blood–tissue barriers — Lesson from the testis. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:1, pages 141-153.
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T. Sathish Kumar, E. Sugantha Priya, P. Raja Singh & J. Arunakaran. (2017) Lactational exposure of polychlorinated biphenyls downregulates critical genes in Leydig cells of F1 male progeny (PND21). Andrologia 49:8, pages e12734.
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Ahmed Khalil, Mikhail Parker, Sarah E. Brown, Sebnem E. Cevik, Lian W. Guo, Jake Jensen, Alexandra Olmsted, Daneal Portman, Haotian Wu & Alexander Suvorov. (2017) Perinatal exposure to 2,2′,4′4′ −Tetrabromodiphenyl ether induces testicular toxicity in adult rats. Toxicology 389, pages 21-30.
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Debarshi Sarkar & Shio Kumar Singh. (2017) Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring. Toxicology 386, pages 103-119.
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Ying Gao, Haiqi Chen, Xiang Xiao, Wing-yee Lui, Will M. Lee, Dolores D. Mruk & C. Yan Cheng. (2017) Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2. Scientific Reports 7:1.
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Jing Zhang, Shuguang Jin, Jinchang Zhao & Huan Li. (2016) Effect of dibutyl phthalate on expression of connexin 43 and testosterone production of leydig cells in adult rats. Environmental Toxicology and Pharmacology 47, pages 131-135.
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Nan Li, Dolores D. Mruk, Haiqi Chen, Chris K. C. Wong, Will M. Lee & C. Yan Cheng. (2016) Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43. Scientific Reports 6:1.
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Joaquín Paillamanque, Cristian Madrid, Emerson M. Carmona, Nelson Osses, Ricardo D. Moreno, Gerardo M. Oresti, José A. Pino & Juan G. Reyes. (2016) Effects of Fatty Acids on Intracellular [Ca2+], Mitochondrial Uncoupling and Apoptosis in Rat Pachytene Spermatocytes and Round Spermatids. PLOS ONE 11:7, pages e0158518.
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Katarzyna Chojnacka, Barbara Bilinska & Dolores D. Mruk. (2016) Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication. Cellular Signalling 28:5, pages 469-480.
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Nan Li, Dolores D. Mruk, Ka‐Wai Mok, Michelle W. M. Li, Chris K. C. Wong, Will M. Lee, Daishu Han, Bruno Silvestrini & C. Yan Cheng. (2015) Connexin 43 reboots meiosis and reseals blood‐testis barrier following toxicant‐mediated aspermatogenesis and barrier disruption. The FASEB Journal 30:4, pages 1436-1452.
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Keith M. Goldstein, David E. Seyler, Philippe Durand, Marie-Hélène Perrard & Thomas K. Baker. (2016) Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants. Reproductive Toxicology 60, pages 92-103.
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Jonathan Gerber, Julia Heinrich & Ralph Brehm. (2016) Blood–testis barrier and Sertoli cell function: lessons from SCCx43KO mice. REPRODUCTION 151:2, pages R15-R27.
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Gerald M. Kidder & Daniel G. Cyr. (2016) Roles of connexins in testis development and spermatogenesis. Seminars in Cell & Developmental Biology 50, pages 22-30.
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C. Yan Cheng & Dolores D. Mruk. 2015. Sertoli Cell Biology. Sertoli Cell Biology 333 383 .
Ying Gao, Will M. Lee & C. Yan Cheng. (2014) Thyroid Hormone Function in the Rat Testis. Frontiers in Endocrinology 5.
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N. Ece Gungor-Ordueri, Elizabeth I. Tang, Ciler Celik-Ozenci & C. Yan Cheng. (2014) Ezrin is an Actin Binding Protein That Regulates Sertoli Cell and Spermatid Adhesion During Spermatogenesis. Endocrinology 155:10, pages 3981-3995.
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James M. Hotaling & Zamip Patel. (2014) Male Endocrine Dysfunction. Urologic Clinics of North America 41:1, pages 39-53.
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Hin-Ting Wan, Dolores D. Mruk, Chris K. C. Wong & C. Yan Cheng. (2014) Perfluorooctanesulfonate (PFOS) Perturbs Male Rat Sertoli Cell Blood-Testis Barrier Function by Affecting F-Actin Organization via p-FAK-Tyr407: An in Vitro Study. Endocrinology 155:1, pages 249-262.
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Lianglin Qiu, Xuhui Zhang, Xiaoming Zhang, Yudong Zhang, Jun Gu, Minjian Chen, Zhan Zhang, Xinru Wang & Shou-Lin Wang. (2013) Sertoli Cell Is a Potential Target for Perfluorooctane Sulfonate–Induced Reproductive Dysfunction in Male Mice. Toxicological Sciences 135:1, pages 229-240.
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Martine Culty. (2013) Gonocytes, from the Fifties to the Present: Is There a Reason to Change the Name?1. Biology of Reproduction 89:2.
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Hin-Ting Wan, Dolores D. Mruk, Chris K.C. Wong & C. Yan Cheng. (2013) The apical ES–BTB–BM functional axis is an emerging target for toxicant-induced infertility. Trends in Molecular Medicine 19:7, pages 396-405.
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Ajeet Pratap Singh, Connie A. Cummings, Yuji Mishina & Trevor K. Archer. (2013) SOX8 Regulates Permeability of the Blood-Testes Barrier That Affects Adult Male Fertility in the Mouse1. Biology of Reproduction 88:5.
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K. Knapczyk-Stwora, M. Grzesiak & M. Slomczynska. (2013) In utero exposure to the anti-androgen flutamide influences connexin 43 and β-catenin expression in porcine fetal gonads. Domestic Animal Endocrinology 44:4, pages 185-194.
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