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Review

New insights into germ cell migration and survival/apoptosis in spermatogenesis

Lessons from CD147

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Pages 264-272 | Published online: 01 Dec 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Hsiao Chang Chan. (2013) Letter from the editor. Spermatogenesis 3:3.
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Articles from other publishers (24)

P. Dai, F. Qiao, Y. Chen, D. Y. L. Chan, H. C. H. Yim, K. L. Fok & H. Chen. (2023) SARS-CoV-2 and male infertility: from short- to long-term impacts. Journal of Endocrinological Investigation 46:8, pages 1491-1507.
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Chao ChenXiaoqing YiPanpan LiuJie LiBei YanDetian ZhangLei ZhuPian YuLei LiJiaxiong ZhangYehong KuangShuang ZhaoWu ZhuCong PengXiang Chen. (2023) CD147 Facilitates the Pathogenesis of Psoriasis through Glycolysis and H3K9me3 Modification in Keratinocytes. Research 6.
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Kathleen Hoi Kei Choy, Sze Yan Chan, William Lam, Jing Jin, Tingting Zheng, Tin Yu Samuel Law, Sidney Siubun Yu, Weiping Wang, Linxian Li, Gangcai Xie, Howard Chi Ho Yim, Hao Chen & Ellis Kin Lam Fok. (2022) The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis. BMC Biology 20:1.
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Jing Jin, Xiaofeng Li, Mei Ye, Feng Qiao, Hao Chen & Kin Lam Fok. (2022) Defb19 regulates the migration of germ cell and is involved in male fertility. Cell & Bioscience 12:1.
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Hao Chen, Xiao Shi, Xiaofeng Li, Ruiying Diao, Qian Ma, Jing Jin, Zhuolin Qiu, Cailing Li, Mei Kuen Yu, Chaoqun Wang, Xianxin Li, Fanghong Li, David Yiu Leung Chan, Allan Zijian Zhao, Zhiming Cai, Fei Sun & Kin Lam Fok. (2021) CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia. Molecular Therapy - Nucleic Acids 26, pages 1374-1386.
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Zhaoyu Zhang, Jun Yu, Jie Xie, Duanya Liu, Yongsheng Fan, Haitao Ma, Chunhong Wang & Zhidan Hong. (2021) Improvement roles of zinc supplementation in low dose lead induced testicular damage and glycolytic inhibition in mice. Toxicology 462, pages 152933.
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Abdelkareem A. Ahmed, Adriano Mollica, Azzurra Stefanucci, Eltayeb Tayrab, Hussain Ahmed & Mohammed Elmujtba Adam Essa. (2020) Gum Arabic improves the reproductive capacity through upregulation of testicular glucose transporters (GLUTs) mRNA expression in Alloxan induced diabetic rat. Bioactive Carbohydrates and Dietary Fibre 22, pages 100218.
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Jun Yu, Jiantao Sun, Yongsheng Fan, Jianmei Su, Jie Xie, Yu Wu, Xi Liu & Chunhong Wang. (2019) Exposure to Pb and Cd alters MCT4/CD147 expression and MCT4/CD147-dependent lactate transport in mice Sertoli cells cultured in vitro. Toxicology in Vitro 56, pages 30-40.
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Rezvan Asgari, Kamran Mansouri, Mitra Bakhtiari & Asad Vaisi-Raygani. (2019) CD147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases’ pathway. Molecular Biology Reports 46:1, pages 1099-1105.
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Shiva Roshankhah, Kamran Mansouri, Mitra Bakhtiari, Mohammad Reza Salahshoor & Rezvan Asgari. (2018) Synergistic effects of TIMP2-418G/C and MMP9-1562C/T variants on the male infertility risk. Molecular Biology Reports 46:1, pages 861-866.
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Nadine Knutti, Otmar Huber & Karlheinz Friedrich. (2018) CD147 (EMMPRIN) controls malignant properties of breast cancer cells by interdependent signaling of Wnt and JAK/STAT pathways. Molecular and Cellular Biochemistry 451:1-2, pages 197-209.
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Chaoqun Wang, Jieting Zhang, Kin L. Fok, Lai L. Tsang, Mei Ye, Jianni Liu, Fanghong Li, Allan Z. Zhao, Hsiao C. Chan & Hao Chen. (2018) CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis. The American Journal of Pathology 188:7, pages 1597-1607.
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Rosario Barone, Alessandro Pitruzzella, Antonella Marino Gammazza, Francesca Rappa, Monica Salerno, Fulvio Barone, Claudia Sangiorgi, Daniela D'Amico, Nicola Locorotondo, Francesca Di Gaudio, Luigi Cipolloni, Valentina Di Felice, Stefania Schiavone, Venerando Rapisarda, Gabriele Sani, Amos Tambo, Francesco Cappello, Emanuela Turillazzi & Cristoforo Pomara. (2017) Nandrolone decanoate interferes with testosterone biosynthesis altering blood-testis barrier components. Journal of Cellular and Molecular Medicine 21:8, pages 1636-1647.
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Viviane Paiva Santana, Cristiana Libardi Miranda-Furtado, Flavia Gaona de Oliveira-Gennaro & Rosana Maria dos Reis. (2017) Genetics and epigenetics of varicocele pathophysiology: an overview. Journal of Assisted Reproduction and Genetics 34:7, pages 839-847.
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Cong Peng, ShengXi Zhang, Li Lei, Xu Zhang, Xuekun Jia, Zhongling Luo, Xiaoyan Huang, Yanhong Kuang, Weiqi Zeng, Juan Su & Xiang Chen. (2017) Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis. Scientific Reports 7:1.
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G. Daniel GrassBryan P. Toole. (2016) How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity. Bioscience Reports 36:1.
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Sarah Heiler, Wei Mu, Margot Zöller & Florian Thuma. (2015) The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities. Cell Communication and Signaling 13:1.
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Wei Li, Jianfang Fu, Shun Zhang, Jie Zhao, Nianlin Xie & Guoqing Cai. (2015) The proteasome inhibitor bortezomib induces testicular toxicity by upregulation of oxidative stress, AMP-activated protein kinase (AMPK) activation and deregulation of germ cell development in adult murine testis. Toxicology and Applied Pharmacology 285:2, pages 98-109.
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Diana Anderson, Thomas Ernst Schmid & Adolf Baumgartner. 2015. Handbook of Fertility. Handbook of Fertility 19 26 .
Lijuan Xiong, Carl EdwardsIIIIII & Lijun Zhou. (2014) The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature. International Journal of Molecular Sciences 15:10, pages 17411-17441.
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Taymour Mostafa, Laila Rashed, Nashaat Nabil & Rania Amin. (2014) Seminal BAX and BCL2 Gene and Protein Expressions in Infertile Men With Varicocele. Urology 84:3, pages 590-595.
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Aihong Jin, Hao Chen, Chaoqun Wang, Lai Ling Tsang, Xiaohua Jiang, Zhiming Cai, Hsiao Chang Chan & Xiaping Zhou. (2014) Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells. Fertility and Sterility 101:6, pages 1681-1687.e1.
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Kin Lam Fok, Hao Chen, Ye Chun Ruan & Hsiao Chang Chan. (2014) Novel regulators of spermatogenesis. Seminars in Cell & Developmental Biology 29, pages 31-42.
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Bifang He, Canquan Mao, Beibei Ru, Hesong Han, Peng Zhou & Jian Huang. (2013) Epitope Mapping of Metuximab on CD147 Using Phage Display and Molecular Docking. Computational and Mathematical Methods in Medicine 2013, pages 1-6.
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