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Review

Dual role of immune cells in the testis

Protective or pathogenic for germ cells?

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Article: e23870 | Received 17 Dec 2012, Accepted 02 Feb 2013, Published online: 01 Jan 2013

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Crossref
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Crossref
Jorge Moreno-Fernandez, María J. M. Alférez, Inmaculada López-Aliaga & Javier Diaz-Castro. (2019) Protective effects of fermented goat milk on genomic stability, oxidative stress and inflammatory signalling in testis during anaemia recovery. Scientific Reports 9:1.
Crossref
Weihua Liu, Ruiqin Han, Han Wu & Daishu Han. (2018) Viral threat to male fertility. Andrologia 50:11, pages e13140.
Crossref
Vanesa A. Guazzone. (2018) Exploring the role of antigen presenting cells in male genital tract. Andrologia 50:11, pages e13120.
Crossref
Patricia Jacobo. (2018) The role of regulatory T Cells in autoimmune orchitis. Andrologia 50:11, pages e13092.
Crossref
Estela J. Jauregui, Debra Mitchell, Traci Topping, Cathryn A. Hogarth & Michael D. Griswold. (2018) Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function. Development 145:13.
Crossref
Keiya Nagasawa, Kasane Imura-Kishi, Aya Uchida, Ryuji Hiramatsu, Masamichi Kurohmaru & Yoshiakira Kanai. (2018) Regionally distinct patterns of STAT3 phosphorylation in the seminiferous epithelia of mouse testes. Molecular Reproduction and Development 85:3, pages 262-270.
Crossref
Kate L. Loveland, Britta Klein, Dana Pueschl, Sivanjah Indumathy, Martin Bergmann, Bruce E. Loveland, Mark P. Hedger & Hans-Christian Schuppe. (2017) Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond. Frontiers in Endocrinology 8.
Crossref
Almas R. Juma, Sylvia V. H. Grommen, Moira K. O’Bryan, Anne E. O’Connor, D. Jo Merriner, Nathan E. Hall, Stephen R. Doyle, Pauliina E. Damdimopoulou, Daniel Barriga, Adam H. Hart, Wim J. M. Van de Ven & Bert De Groef. (2017) PLAG1 deficiency impairs spermatogenesis and sperm motility in mice. Scientific Reports 7:1.
Crossref
Shannon Whirledge & John A. Cidlowski. (2017) Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction. Trends in Endocrinology & Metabolism 28:6, pages 399-415.
Crossref
Mónica Frungieri, Ricardo Calandra & Soledad Rossi. (2017) Local Actions of Melatonin in Somatic Cells of the Testis. International Journal of Molecular Sciences 18:6, pages 1170.
Crossref
Junko NOGUCHI, Shinya WATANABE, Thanh Q. Dang NGUYEN, Kazuhiro KIKUCHI & Hiroyuki KANEKO. (2017) Development of a lipopolysaccharide (LPS)-supplemented adjuvant and its effects on cell-mediated and humoral immune responses in male rats immunized against sperm. Journal of Reproduction and Development 63:1, pages 111-115.
Crossref
Masahiro ItohMasahiro Itoh. 2017. Testicular Autoimmunity. Testicular Autoimmunity 123 162 .
Catherine A. Picut, Eveline P. C. T. de Rijk & Darlene Dixon. 2017. Immunopathology in Toxicology and Drug Development. Immunopathology in Toxicology and Drug Development 479 539 .
Qian Jiang & Daishu Han. 2017. Endocrinology of the Testis and Male Reproduction. Endocrinology of the Testis and Male Reproduction 1051 1069 .
Peter G. Stanton. (2016) Regulation of the blood-testis barrier. Seminars in Cell & Developmental Biology 59, pages 166-173.
Crossref
Qiaoyuan Chen, Tingting Deng & Daishu Han. (2016) Testicular immunoregulation and spermatogenesis. Seminars in Cell & Developmental Biology 59, pages 157-165.
Crossref
Britta Klein, Thomas Haggeney, Daniela Fietz, Sivanjah Indumathy, Kate L. Loveland, Mark Hedger, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann & Hans-Christian Schuppe. (2016) Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia. Human Reproduction 31:10, pages 2192-2202.
Crossref
Lilach Marom-Haham & Adrian Shulman. (2016) Cigarette smoking and hormones. Current Opinion in Obstetrics & Gynecology 28:4, pages 230-235.
Crossref
Jinpu Peng, Lianju Shen, Jinjun Chen, Xining Cao, Yue Zhou, Huali Weng, Chunlan Long, Deying Zhang, Shengfen Tu, Yan Zhang, Dawei He, Tao Lin & Guanghui Wei. (2016) New discovery of cryptorchidism: Decreased retinoic acid in testicle. Saudi Pharmaceutical Journal 24:3, pages 279-285.
Crossref
Katarzyna Chojnacka, Marta Zarzycka & Dolores D. Mruk. 2016. Molecular Mechanisms of Cell Differentiation in Gonad Development. Molecular Mechanisms of Cell Differentiation in Gonad Development 225 251 .
Qian Jiang & Daishu Han. 2016. Endocrinology of the Testis and Male Reproduction. Endocrinology of the Testis and Male Reproduction 1 19 .
Michael K Wong, Nicole G Barra, Nadia Alfaidy, Daniel B Hardy & Alison C Holloway. (2015) Adverse effects of perinatal nicotine exposure on reproductive outcomes. REPRODUCTION 150:6, pages R185-R193.
Crossref
Cristian M. Sobarzo, Nogueira de Morais Rosana, Lustig Livia, Denduchis Berta & Helena F. Schteingart. (2015) Mono-(2-ethylhexyl) phthalate (MEHP) affects intercellular junctions of Sertoli cell: A potential role of oxidative stress. Reproductive Toxicology 58, pages 203-212.
Crossref
Cecilia V. Pérez, Leticia G. Gómez, Gisela S. Gualdoni, Livia Lustig, Gabriel A. Rabinovich & Vanesa A. Guazzone. (2015) Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology. Scientific Reports 5:1.
Crossref
M. B. Frungieri, R. S. Calandra, A. Mayerhofer & M. E. Matzkin. (2014) Cyclooxygenase and prostaglandins in somatic cell populations of the testis. Reproduction 149:4, pages R169-R180.
Crossref
S. López-Doval, R. Salgado, B. Fernández-Pérez & A. Lafuente. (2015) Possible role of serotonin and neuropeptide Y on the disruption of the reproductive axis activity by perfluorooctane sulfonate. Toxicology Letters 233:2, pages 138-147.
Crossref
Silvana Peterini Boeira, Vinícius Rafael Funck, Carlos Borges Filho, Lucian Del’Fabbro, Marcelo Gomes de Gomes, Franciele Donato, Luiz Fernando Freire Royes, Mauro Schneider Oliveira, Cristiano Ricardo Jesse & Ana Flávia Furian. (2015) Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice. Chemico-Biological Interactions 230, pages 50-57.
Crossref
Cecilia Valeria Pérez, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, María Noel Galardo, Munekazu Naito, Livia Lustig & Patricia Verónica Jacobo. (2014) IL17A impairs blood–testis barrier integrity and induces testicular inflammation. Cell and Tissue Research 358:3, pages 885-898.
Crossref
Hebatallah A. Darwish, Hany H. Arab & Rania M. Abdelsalam. (2014) Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: Comparison with celecoxib. Toxicology and Applied Pharmacology 279:2, pages 129-140.
Crossref
Kaylon L. Bruner-Tran, Tianbing Ding, Kallie B. Yeoman, Anthony Archibong, Joe A. Arosh & Kevin G. Osteen. (2014) Developmental Exposure of Mice to Dioxin Promotes Transgenerational Testicular Inflammation and an Increased Risk of Preterm Birth in Unexposed Mating Partners. PLoS ONE 9:8, pages e105084.
Crossref
H. Welter, A. Huber, S. Lauf, D. Einwang, C. Mayer, J.U. Schwarzer, F.M. Köhn & A. Mayerhofer. (2014) Angiotensin II regulates testicular peritubular cell function via AT1 receptor: A specific situation in male infertility. Molecular and Cellular Endocrinology 393:1-2, pages 171-178.
Crossref
Gurvinder Kaur, Lea Ann Thompson & Jannette M. Dufour. (2014) Sertoli cells – Immunological sentinels of spermatogenesis. Seminars in Cell & Developmental Biology 30, pages 36-44.
Crossref
Terje Svingen & Peter Koopman. (2013) Building the mammalian testis: origins, differentiation, and assembly of the component cell populations. Genes & Development 27:22, pages 2409-2426.
Crossref