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Abstract
Background: In 2009 and 2011 respectively ESVS and AHA/ASA guidelines recommended to operate patients with a symptomatic carotid artery stenosis within 14 days. This study aimed primarily to determine if an academic hospital has implemented these international guidelines about indication and timing of surgical treatment of carotid stenosis. Second, the influence of referral from another hospital on time from symptoms to surgery and the influence of time between neurological event and surgery on 30-day complication rate was studied. Third, the number of asymptomatic carotid artery lesions treated surgically was also evaluated in both periods.
Methods: Retrospective study to compare patients with significant atherosclerotic carotid stenosis who underwent carotid endarterectomy (CEA) or carotid artery stenting (CAS) in 2005–2006 versus patients treated in 2014–2016. Demographic data, treatment characteristics, interval between symptom and surgery and 30-day outcomes were collected.
Results: In 2005–2006 38.1% (59/155) of the patients were treated for symptomatic carotid artery stenosis, in 2014–2016 this increased to 66.5% (121/182) (p < .001, 95% CI: 0.179–0.383). Median time from neurological symptom to surgery in symptomatic patients decreased from 30 to 13 d (p <.001, 95% CI: 1.476–2.763). Early surgery did not increase the 30-day postoperative complications (p = .19, 95% CI: 0.987–1.003). Referral from another hospital almost doubled the time interval between symptoms and surgery in 2014–2016 (p <.001, 95% CI: 1.386–2.827).
Conclusions: Since the publication of the international guidelines, patients with symptomatic carotid artery stenosis were preferably surgically treated within 2 weeks at an academic institution. The number of treated asymptomatic carotid stenoses was drastically reduced.
Disclosure statement
Isabelle Van Herzeele is consultant for Medtronic Academia (Tolochenaz, Swiss) and Silk Road Medical (Sunnyvale, CA). Frank Vermassen is consultant for Medtronic Academia (Tolochenaz, Swiss), W.L. Gore & Associates (Flagstaff, USA), Abbott Vascular (Illinois, CA) and Cordis Corporation (Fremont, CA). These relationships played no role in the design and conduct of the study, nor in the collection, management, analysis, and interpretation of data nor in the preparation of the manuscript. For the remaining authors, no conflicts of interest or financial ties are declared.