Papillary thyroid carcinoma with hobnail features showing rapid progression and therapy resistance

Abstract

Background

Hobnail variant of papillary thyroid carcinoma (HVPTC), also designated as a micropapillary variant, is a rare but aggressive variant of PTC, representing <2% of all PTC. It was adopted in the newest World Health Organization classification. HVPTC is strongly associated with higher mortality in comparison to classic PTC and a high propensity for disease progression. This paper aimed to investigate the clinical course, cytological and histopathological features, and mutational profile of the hobnail variant from a unique case.

Case report

A case of a 38-year-old female patient with HVPTC is presented. Total thyroidectomy with central and bilateral, lateral lymphadenectomy was performed. The clinical course showed aggressive features, as lymph node metastasis and extrathyroidal extension were present at the presentation. Molecular and immunohistochemical features are addressed along with a review of the literature.

Discussion

The cytological examination of FNA was in consonance with published literature. The cells showed hobnail features in several segments of both thyroidal lobes on histological examination. The tumour displayed a typical BRAF mutation and Gly12Ala mutation in the KRAS gene, previously not associated with PTC.

Conclusion

We aimed to highlight the aggressive, clinicopathological features of this high-risk variant. We emphasise the need to evaluate suspicious thyroid nodules as an adequate diagnosis can prevent delayed therapy. It directly impacts the tumour’s stage and prognosis. In fine-needle aspiration cytology showing papillary architecture carcinomas, HVPTC has to be part of the differential diagnosis.

Keywords:

• Cytopathology
• immunohistochemistry
• papillary thyroid carcinoma
• hobnail variant
• micropapillary variant
• BRAF

Acknowledgements

A particular word of gratitude goes to Dr. Sam Van Slycke, who contributed to constructive cooperation as a diligent and reliable supervisor. Furthermore, Dr. Vanessa Meert is acknowledged for performing extended histopathological investigations.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.