Abstract
Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs).
Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS).
Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal.
Results: We found significantly lower total symptom score (TSS) during the 7th (p = .009), 14th (p = .003), 21st (p < .001) and the 28th day (p = .001), lower total endoscopic score (TES) on the 21st (p = .002) and 28th day (p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water.
Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.
Chinese abstract
背景:阿司匹林致慢性鼻窦炎(CRS)是一种严重的进行性持续性疾病, 通常与鼻息肉(NPs)有关。
目的:比较高渗(2.3%氯化钠)海水和等渗0.9%氯化钠对鼻内镜手术后1个月内患者症状和内镜表现的影响。
材料和方法:这项前瞻性随机研究包括30例正在接受ESS的阿司匹林诱导的CRS患者。将患者分为两组, 每组15名受试者, 每组使用两种鼻腔冲洗液中的一种。在移除鼻包后的第1、7、14、21和28天, 评估5种症状(鼻塞、鼻腔分泌物/鼻后滴液、面部疼痛/压力、头痛和睡眠障碍)的程度和内镜检查结果。
结果:我们发现, 经高渗海水治疗的患者在第7天(p = 0.009)、第14天(p = 0.003)、第21天(p < 0.001)和第28天(p = 0.001)的总症状评分(TSS)明显较低;在第21天(p = 0.002)和第28天(p = 0.001)的总内窥镜评分(TES)较低;鼻阻塞、面部疼痛/压力、头痛和睡眠困难较低;鼻粘膜水肿、鼻分泌物和鼻部结痂较低。
结论及意义:在阿司匹林致CRS患者术后早期护理中, 建议采用高渗海水冲洗液。
Acknowledgments
This investigation was conducted as a part of scientific project of the Military Medical Academy Faculty of Medicine (MFVMA 02/19-21/).
Disclosure statement
The authors declare that they have no conflict of interest.