Clinical application of 3D-VOG analysis for quantitative evaluation of Otolith-Ocular reflex in the roll and pitch planes

Abstract

Background

Management of vestibular falls requires precise evaluation of otolithic function and gravity recognition. Tilt of the head in the roll plane causes ocular counter rolling (OCR) with a gain of 5–10%, which can be a quantitative parameter related to the otolith-ocular reflex (OOR) in that plane. However, the OOR in the pitch plane is indiscernible because of our ability to voluntarily gaze and pursue. 3 D eye movements and its Listing’s plane description can provide novel parameters with which to evaluate OOR, even in the pitch plane.

Objectives

To evaluate the utility of 3 D eye movement analysis in video oculography (VOG) as a quantitative parameter reflecting otolithic function during head movements associated with daily life.

Materials and methods

In healthy subjects, we analyzed the changes in 3 D eye movements and the Listing’s plane that occur with static gravitational modification.

Results

OOR during head tilt in the roll plane revealed that OCR amplitude had a saturating/peaked conformation and was not fitted by a sine curve. OOR in the pitch plane revealed anteroposterior leaning of the Listing’s plane.

Conclusions

These novel tools for minimally invasive evaluation of OOR in a clinical setting could potentially enable us to quantitatively evaluate peripheral static disequilibrium.

Chinese abstract

背景：前庭跌倒的治疗需要对耳石功能和重力识别的精确评估。头部在侧倾平面上的倾斜会导致眼底反向滚动（OCR）, 其增益为5-10％, 这可能是与该平面上耳石-眼反射（OOR）相关的定量参数。但是, 由于我们具有自动凝视和追视的能力, 在俯仰平面上的OOR是不可识别的。 3D眼动及其Listing平面描述可以提供新的参数, 并可用来评估OOR, 即使是在俯仰平面上。

目的：评价3D眼动分析在视频眼动术（VOG）中的实用性, 作为反映与日常生活相关的头部运动过程中耳石功能的定量参数。

材料和方法：在健康的受试者中, 我们分析了3D眼动和静态引力作用下Listing平面的变化。

结果：头部在侧倾平面上倾斜时的OOR显示OCR振幅具有饱和/峰值构型, 并且不符合正弦曲线。在俯仰平面上的OOR显示Listing平面的前后倾斜。

结论：这些新工具可用于临床对OOR进行微创评估, 并可能使我们能够定量评估外周静态不平衡。

Keywords:

• 3-dimensional
• eye movement
• Listing’s plane
• otolith
• ocular counter-rolling

Disclosure statement

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Funding

This work was supported by JSPS KAKENHI Grant Number JP17K11314.