Developmental performance between pediatric cochlear implantation candidates with and without large vestibular aqueduct syndrome

Abstract

Background

We are inclined to pay special care and attention to children with large vestibular aqueduct syndrome (LVAS). However, it is not clear whether children with LVAS have more developmental delays than children without LVAS.

Objectives

To compare the developmental performance between pediatric cochlear implantation (CI) candidates with and without LVAS.

Materials and methods

Medical records of pediatric CI candidates were reviewed. Through propensity score matching analysis, 70 children with LVAS and 70 gender-, age-, and auditory-matched children were recruited as the LVAS and non-LVAS group, respectively. Developmental performances were compared between the two groups.

Results

Compared with normal developmental metrics, both LVAS and non-LVAS groups had developmental delay in multiple domains (both p < .001). Although some differences in motor developments between children with LVAS and without LVAS, they demonstrated overall equal developmental levels in both verbal and nonverbal aspects (all p > .05). Age of intervention was the primary risk factor for developmental performance of LVAS children (β < 0, p < .05) with an obvious delay starting at 1 year of age.

Conclusion

Pediatric CI candidates with LVAS had both verbal and nonverbal developmental delays. However, they exhibited similar overall developmental performances to those without LVAS.

Chinese abstract

背景：我们倾向于对患有大前庭水管综合征（LVAS）的儿童给予特别的照顾和关注。然而, 与非LVAS儿童相比, LVAS儿童是否发育更迟缓, 对此还不甚明了。

目的：比较有和没有LVAS的人工耳蜗植入（CI）儿童的发育表现。

材料和方法：审查了儿科CI候选人的病历。通过倾向得分匹配分析, 分别招募了70名LVAS儿童和70名性别、年龄和听觉相对应的儿童作为LVAS和非LVAS组。比较两组的发育表现。

结果：与正常的发育指标相比, LVAS组和非LVAS组在多个方面都有发育迟缓（两组均p <.001）。尽管有LVAS的儿童和没有LVAS的儿童在运动发育方面存在一些差异, 但他们在语言和非语言方面都表现出总体上相等的发育水平（p> .05）。干预年龄是LVAS儿童发育表现的主要危险因素（b <0, p <.05）, 从1岁开始明显迟缓。

结论：LVAS儿童CI候选人在语言和非语言发育上都有迟缓。然而, 它们显示出与非LVAS儿童的相似的总体发育表现。

Keywords:

• Children
• cochlear implantation
• large vestibular aqueduct syndrome
• developmental performance

Disclosure statement

No potential conflict of interest was reported by the author(s).