Treatment outcomes in patients with supraglottic laryngeal cancer: a single centre study

Abstract

Background

Treatment of squamous cell carcinoma of the supraglottic larynx (SCCSL) in Denmark has changed in several ways from the year 2000 to 2014, including the introduction of IMRT radiation technique and the addition of concurrent chemotherapy (CRT), as well as systematic reduction in waiting times until treatment initiation.

Aim/Objectives

Our aim is to investigate the effect of the abovementioned factors on overall survival (OS) and locoregional control (LC) for SCCSL patients.

Materials and methods

Retrospective cohort study with data from the DAHANCA database. We used the Kaplan–Meier and Cumulative Incidence plots as well as Cox regression analysis.

Results

We found a statistically significant improvement of the 5-year OS of 19.3 percentage points (pp). Cox regression found LC was not improved in patients receiving CRT compared to radiotherapy (RT) alone.

Conclusions and significance

Introduction of CRT treatment for head and neck cancers in general is known to improve LC. We could not demonstrate this effect for SCCSL specifically, as our results were not statistically significant on this point. OS was significantly improved.

Chinese abstract

背景：从2000年到2014年, 丹麦对声门上喉鳞状细胞癌（SCCSL）的治疗在多种方面发生了变化, 包括引入IMRT放射技术, 增加同时化疗（CRT）以及系统性减少等待开始治疗时间。

目的：我们的目的是研究上述方面对SCCSL患者的总生存期（OS）和局部控制（LC）的影响。

材料和方法：回顾性队列研究, 数据来自DAHANCA数据库。我们使用了Kaplan–Meier和累积发生率图以及Cox回归分析。

结果：我们发现5年OS的统计学显著改善为19.3个百分点（pp）。 Cox回归分析发现, 与单独放疗（RT）相比, 接受CRT的患者的LC并没有改善。

结论和意义：众所周知, 对头颈癌采用CRT治疗可改善LC。可是我们无法具体表现对SCCSL也会有这种效果, 因为我们的结果在这一点上没有统计学意义。总生存期得到了显著改善。

Keywords:

• Chemoradiotherapy
• chemotherapy
• outcomes
• supraglottic carcinoma
• larynx
• recurrence
• DAHANCA

Disclosure statement

No potential conflict of interest was reported by the author(s).