Influences of alcohol/polyols on interaction of moxifloxacin hydrochloride through cetyltrimethylammonium bromide at numerous temperatures and compositions

Abstract

A study on the interaction of a fourth-generation antibiotic drug, moxifloxacin hydrochloride (MFH), with a cationic surfactant, such as cetyltrimethylammonium bromide (CTAB) in the aqueous solution of alcohol (1-propanol (1-PrOH)) and polyols (galactose/maltose), has been carried out using the conductivity measurement technique. The critical micelle concentration (cmc), micelle ionisation (α), counter ion binding (β), and thermodynamic properties ($\mathrm{\Delta }{G}_m^0$, $\mathrm{\Delta }{H}_m^0$, and $\mathrm{\Delta }{S}_m^0$) for the self-aggregation of MFH + CTAB mixture have been estimated in 1-PrOH/polyols solutions. The presence of 1-PrOH delays the MFH + CTAB micelle formation, whereas polyols create a congenial environment for the micelle formation. In 1-PrOH, the values of α experience a reduction with the increase of 1-PrOH concentration and temperature. The values of α were found to be dependent on the concentration of other additives. In all of the cases thoroughly studied, the values of $\mathrm{\Delta }{G}_m^0$ were found negative, which experience an enhancement in polyols solutions and decreased in 1-PrOH solution. On the basis of $\mathrm{\Delta }{H}_m^0$ and $\mathrm{\Delta }{S}_m^0$ values, the suggested interaction forces between MFH and surfactant are hydrophobic, ion-dipole, and electrostatic in nature. The values of $\mathrm{\Delta }{H}_m^{0,\ast }$ reveal that the micelle is more stable in polyols media than that of the 1-PrOH medium.

GRAPHICAL ABSTRACT

KEYWORDS:

• Moxifloxacin hydrochloride
• polyols (galactose/maltose)
• conductivity measurement
• thermodynamic parameters
• hydrophobic/ion-dipole/electrostatic interaction

Acknowledgment

Authors are grateful to the Researchers Supporting Project Number (RSP-2021/360), King Saud University, Riyadh, Saudi Arabia.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Authors are grateful to the Researchers Supporting Project Number (RSP-2021/360), King Saud University, Riyadh, Saudi Arabia.