Experimental determination and correlation of bosentan solubility in (PEG 200 + water) mixtures at T= (293.15–313.15) K

ABSTRACT

The solubility of bosentan (BST) in the aqueous mixtures of polyethylene glycol 200 (PEG 200) at the temperature range, T = (293.15–313.15) K, has been studied using a shake-flask method. The experimental solubility data were correlated with Jouyban–Acree, Jouyban-Acree-van’t Hoff, modified Wilson and Yalkowsky models. Deviations of the calculated solubility from experimental one were determined by percent average relative deviations and relative deviations. In addition, to represent the thermodynamic behaviour of BST in PEG 200 solutions, the apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of dissolution were obtained by using the van’t Hoff and Gibbs equations.

KEYWORDS:

• Solubility
• bosentan
• polyethylene glycol 200
• binary solvent mixture
• Jouyban–Acree model
• van’t Hoff equation
• modified Wilson model

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

S. N. Mirheydari acknowledges the postdoctorate grant of the Tabriz University of Medical Sciences, IRAN [693118] for supporting this work.