Solubility and thermodynamic properties of N-acetylglucosamine in mono-solvents and binary solvents at different temperatures

ABSTRACT

The solubility data of N-acetylglucosamine in five pure solvents (water, methanol, ethanol, n-propanol and acetone) and two binary solvents (water + ethanol, water + acetone) were measured by gravimetric method at temperatures from 283.15 to 313.15 K under atmosphere pressure (p = 101 kPa). The solubility data show that the solubility of N-acetylglucosamine in pure solvents increases with the increasing temperature and the solubility in binary solvents is affected by temperature and solvent composition. The solubility data of N-acetylglucosamine in pure solvents were correlated by Van’t Hoff model, modified Apelblat model, λh model and the modified Apelblat model has the best performance. Jouyban-Acree model was used to correlate the solubility data of N-acetylglucosamine in binary solvents and the fitting performance was well. The dissolution thermodynamic properties of N-acetylglucosamine in all solvents were also estimated in this work. The experimental data will be helpful for purification process of N-acetylglucosamine in industry.

KEYWORDS:

• N-acetylglucosamine
• solubility
• thermodynamic model
• thermodynamic properties

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Shanghai Municipal Science and Technology Commission, Domestic Cooperation Industrialization Project under grant number 18595800900.