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Physics and Chemistry of Liquids
An International Journal
Volume 59, 2021 - Issue 1
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Articles

Determination of the solubility and thermodynamic properties of albendazole in a binary solvent of ethanol and water

Wen-Zhu YangDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Guo-Qing FanDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Ting-Ting ZhangDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Dong-Bo LiDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Lin-Lin PeiDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Ruo-Yue HuangDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Dai-Ping YinDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Li ZhangDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Guang-Neng PengDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Gang ShuDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Zhi-Xiang YuanDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Ju-Chun LinDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Wei ZhangDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Zhi-Jun ZhongDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
,
Li-Zi YinDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of China
&
Hua-Lin FuDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1-11 | Received 28 Feb 2019, Accepted 25 Aug 2019, Published online: 24 Sep 2019
 
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ABSTRACT

The solubility of albendazole (ABZ) in a binary system of ethanol and water were determined experimentally by using a static analytical method within the temperature range (288.95 to 317.25) K under atmospheric pressure (p = 0.1 MPa). It was observed that the solubility of ABZ is not only depended on temperature but also related to the mole fraction of ethanol. Additionally, the obtained solubility data were correlated by employing the CNIBS/R-K model, the modified Apelblat equation and the Jouyban–Acree model. The modified Apelblat equation was proven to give good representation of the experimental solubility data. On the base of the measured solubility, the thermodynamic properties of the dissolution process were calculated. Dissolution of ABZ in these mixed solvents is endothermic, non-spontaneous and enthalpy-driving. This study provides useful information for the design and development of dosage forms of ABZ.

Disclosure statement

No potential conflict of interest was reported by the authors.

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