Solubility of paracetamol in the ternary solvent mixtures of water + ethanol + glycerol at 298.2 and 303.2 K

ABSTRACT

The solubility of paracetamol in the ternary mixtures of water + ethanol + glycerol at 298.2 and 303.2 K is determined via the shake-flask method. The reported data extend the solubility database for paracetamol in various solvent mixtures and also is employed to investigate the prediction capability of the cosolvency models for solubility prediction in the sub-binary and the ternary solvent systems. The solubility data are correlated with some cosolvency models and their accuracies are evaluated by the mean relative deviation (MRD) computed for back-calculated solubilities. The results show that the investigated models fit well and can be applied to the ternary solvent system, and the experimental data is relatively more consistent with the calculated values. The prediction ability of the trained Jouyban-Acree model for predicting drug solubility behaviour in the corresponding sub-binary systems is also investigated.

KEYWORDS:

• Paracetamol
• ternary solvents
• solubility prediction
• Jouyban-Acree model

Acknowledgements

This report is a part of the results of O. Azarmir’s Pharm.D thesis submitted to the Faculty of Pharmacy, Tabriz University of Medical Sciences and the authors would like to thank the Research Affairs, Tabriz University of Medical Sciences, Tabriz, Iran for the financial support.

Disclosure statement

The authors declare no conflict of interest.