Abraham model solute descriptors for two additional α-amino acids: D-Tryptophan and L-Tyrosine

ABSTRACT

Abraham model solute descriptors have been determined for the zwitterionic forms of D-tryptophan and L-tyrosine based on published mole fraction solubility data. The calculated solute descriptors describe the observed solubility data to within standard errors of 0.122 log units (or less). Treatment of each amino acid as a non-zwitterionic molecular compound led to significantly larger standard errors than were observed for the zwitterion form.

KEYWORDS:

• α-amino acids
• Abraham model
• solute descriptors
• molar solubility ratios
• zwitterionic solutes

Acknowledgments

Ramya Motati thanks the University of North Texas’s Texas Academy of Mathematics and Science (TAMS) program for providing a summer research scholarship award.

Disclosure statement

No potential conflict of interest was reported by the authors.