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Clinical focus: Gastroenterology, Hepatology & Nephrology - Original Research

Clinical characteristics of platelets and its possible gender dimorphism in patients with nonalcoholic fatty liver disease (NAFLD)

, , , &
Pages 299-306 | Received 29 Jul 2020, Accepted 10 Sep 2020, Published online: 23 Sep 2020
 

ABSTRACT

Objective

This study aimed to analyze the characteristics of platelet-associated parameters in nonalcoholic fatty liver disease (NAFLD) patients with varying degrees of disease severity and investigate the sexual dimorphism of platelet features in NAFLD patients.

Methods

A total of 829 NAFLD patients were divided into separate groups based on body mass index (BMI), liver stiffness measurement (LSM), controlled attenuation parameter (CAP), and alanine aminotransferase (ALT) levels. The platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) parameters were analyzed among different groups, and the sex-based differences were compared.

Results

The PC decreased with age in both sexes; in 30–59-year-old female subjects, the PC decreased by a conspicuous margin. The MPV increased with age in females, but not in males. The PDW increased significantly in females aged 30–59 years. With the increase in BMI and CAP, the PC showed a decreasing trend. The MPV increased with the increasing CAP value in male patients. With the increasing LSM value, the PC displayed a decreasing trend.

Conclusion

The PC showed marked sex-based differences in NAFLD patients and is affected by age and BMI. Regular changes of platelet parameters could be found in patients with varying degrees of NAFLD. These changes might be helpful in assessing the severity of NAFLD.

Ethics approval and consent to participate

The study was approved by the Ethics Committee of China-Japan Union Hospital of Jilin University (permission number: 2016ks009).

Declaration of interest

The authors declare that they have no financial and non-financial competing interests.

List of abbreviation

NAFLD=

nonalcoholic fatty liver disease

PLT=

Platelet

PC=

Platelet Count

MPV=

Mean platelet volume

PDW=

Platelet distribution width

LSM=

Liver stiffness measurement

CAP=

controlled attenuation parameter

BMI=

body mass index

ALT=

Alanine aminotransferase

AST=

Aspartate aminotransferase

GGT=

γ-glutamyl transpeptadase

ALP=

alkaline phosphatase

ALB=

albumin

TG=

triglycerides

CHOL=

- cholesterol

LDL-C=

Low-density lipoprotein cholesterol

HDL-C=

high-density lipoprotein cholesterol

Glu=

glucose

UA=

uric acid

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