Association between serum vitamin C and chronic kidney disease among adults in NHANES, 2017-2018

ABSTRACT

Objective

The current study evaluated the relationship between serum vitamin C and chronic kidney disease.

Methods

The database from the National Health and Nutrition Examination Survey (NHANES, 2017–2018) was used to perform a cross-sectional study. Multivariate logistic regression was performed to analyze the relationship between serum vitamin C and chronic kidney disease (CKD), and stratified analysis by sex was performed to assess whether there were sex differences in the association between serum vitamin C and CKD.

Results

Before stratified analysis, multivariate logistic regression showed that serum vitamin C was negatively associated with CKD in all models (All OR > 1, P< 0.05), the risk of CKD decreased by one quantile increase in serum vitamin C (P for trend< 0.001) and low vitamin C status was associated with a higher risk of CKD (All OR > 1, P< 0.05). Stratified analyses by sex showed that the association between serum vitamin C and CKD remained negative in men, but not in women.

Conclusion

There were a negative correlation between serum vitamin C and CKD, low levels of vitamin C were associated with a higher risk of CKD, and these associations were only found in men, but not in women.

KEYWORDS:

• Vitamin C
• chronic kidney disease
• sex
• relationship
• public health
• NHANES

Declaration of financial/other relationships

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Data availability statement

Derived data supporting the findings of this study are available from the corresponding author on reasonable request.

Additional information

Funding

This paper was not funded.