The predictive value of procalcitonin in ventilator-associated pneumonia after cardiac valve replacement

Abstract

This study aimed to evaluate the predictive value of procalcitonin (PCT) in ventilator-associated pneumonia (VAP) after cardiac valve replacement. A total of 80 patients who underwent cardiac valve replacement in our department were enrolled in this study. Of these patients,40 were diagnosed with VAP and assigned to the observation group, while the other 40 patients not diagnosed with VAP were assigned to the control group. The changes in serum PCT, white blood cell count and C-reactive protein (CRP) were observed before each operation (T0), on the first day after the operation (T1), the second day after the operation (T2) and the third day after the operation (T3). After the operation, the serum PCT in the observation group was significantly higher than those at different time points after the operation, and also significantly higher than those in the control group (p < .05). In the control group, PCT was significantly higher after the operation than before the operation (p < .05), but the differences among the different postoperative time points were not statistically significant (p > .05). In the two groups, the white blood cell count and CRP were significantly higher after the operation than before the operation (p < .05), but the differences between the two groups were not statistically significant (p > .05). Serum PCT is an early, sensitive and highly specific high-risk monitoring index and has an early prediction value for VAP after cardiac valve replacement.

Keywords:

• Procalcitonin
• heart valves
• hospital acquired pneumonia
• blood cell count
• c-reactive protein

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by First-Class Discipline Construction Founded Project of Ningxia Medical University and the School of Clinical Medicine (No.: NXYLXK2017A05) and 2018 Innovation and Entrepreneurship Project for Overseas Students in Ningxia Province.