Exploration of endoscopic findings and risk factors of early gastric cancer after eradication of Helicobacter pylori

Abstract

Aim

To explore the endoscopic features and risk factors of early gastric cancer (EGC) after eradication of Helicobacter pylori (H. pylori).

Methods

A total of 1961 patients who underwent esophago-gastro-duodenoscopy (EGD) with a history of successful H. pylori eradication were enrolled in this multicenter research. Among them, 162 EGC lesions of 132 patients were detected. The endoscopic features and risk factors of post-eradication EGC were explored.

Results

Severe atrophy (75.3% vs. 16.7%, p value <.01), intestinal metaplasia (96.3% vs. 77.1%, p value <.01), map-like redness (89.5% vs. 65.4%, p value <.01), distinct intermediate zone (IZ) (68.5% vs. 23.4%, p value <.01) and xanthoma (58.0% vs. 17.9%, p value <.01) were significantly more frequent in the CA group (patients with newly detected EGC after eradication of H. pylori) than in the NC group (patients without gastric cancer after eradication of H. pylori). In multivariate analysis, severe atrophy (odds ratio (OR) = 8.08; 95% confidence interval (CI), 3.43–20.0; p value<.01), map-like redness (OR = 1.75; 95% CI, 0.11–5.25; p value = .04), distinct IZ (OR = 2.87; 95% CI, 1.20–6.93; p value = .02) and xanthoma (OR = 2.84; 95% CI, 1.20–7.03; p value=.02) were proved to be risk factors for detection of EGC after eradication of H. pylori.

Conclusions

Severe atrophy and map-like redness and distinct IZ and xanthoma are risk factors of EGC after eradication of H. pylori.

Keywords:

• Early gastric cancer
• eradication of Helicobacter pylori
• endoscopic
• intermediate zone

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

This work was supported by Top-Level Clinical Discipline Project of Shanghai Pudong [PWYgf 2018-04] and the Fundamental Research Funds for the Central Universities [No. 22120180594].