Abstract
Objective
The relationship between the disease activity of ulcerative colitis and fatigue is unclear. We investigated how reaching deep remission versus remaining in active disease influenced the severity of fatigue.
Materials and methods
We included 149 consecutive patients in a longitudinal study. Patients were re-examined after 3 months of conventional treatment and dichotomized into A: Active disease or B: Deep remission. The Partial Mayo Score (PMS) was recorded in all patients. Fatigue was rated using the fatigue visual analog scale (fVAS), Fatigue Severity Scale (FSS), and Short Form-36 Vitality Subscale (SF-36vs). A control group of 22 age and sex-matched healthy subjects were included as controls for patients reaching deep remission.
Results
After 3 months there were no significant differences in fVAS, FSS and SF-36vs scores in patients with active disease compared to patients reaching deep remission, when adjusting for baseline fatigue scores. Patients in remission based on MES-UC scores had no significant reduction in fatigue scores, whereas patients in remission based on PMS had all three fatigue scores reduced. However, patients reaching deep remission still had higher fVAS and lower SF-36vs scores compared to healthy control subjects.
Conclusions
After 3 months of conventional treatment there were no differences in fatigue severity in patients reaching deep remission compared with patients still having active disease. Fatigue was more pronounced in patients in deep remission than in healthy subjects, and was associated with subjective and not objective measures of disease activity. This indicates that other potent factors than inflammation influence fatigue in UC.
ClinicalTrials.gov identifier:
Acknowledgements
The following doctors at the Unit of Gastroenterology, Department of Internal Medicine, Stavanger University Hospital, are thanked for their efforts during study visits: Svein Størset, Hans Jakob Jaatun, Anne Kristine Hetta, Espen Tvedt-Gundersen, Rune Gjerde, and Olivia Slettebakk. The excellent work from study nurses Merethe Lie Seglem, Olaug Lyche, Anne Brit Hellestø Meling, Eva Jensen, Janna Kyllingstad, Jorunn Ree, Siv Hege Baerøy, and Inger Johanne Bø was also highly appreciated.
Disclosure statement
T.G. has served as a speaker for Ferring Pharmaceuticals, Takeda, and advisory board member for Takeda, Janssen-Cilag and Tillotts Pharma. A.C. has served as a speaker and advisory board member for Tillotts Pharma. The other authors report no conflicts of interest.