Abstract
Objectives
To examine conditional survival (CS) in patients with non‐metastatic intrahepatic cholangiocarcinoma (nmICC) after surgical treatment according to pT and pN stages.
Methods
A total of 608 patients were included. Conditional three-year cancer-specific mortality estimates were obtained according to pT and pN stages. Multivariable Cox regression analysis was applied to predict factors affecting cancer-specific mortality (CSM).
Results
According to substages based on pT and pN status, 109 patients (17.9%) with pT1aN0, 96 (15.8%) with pT1bN0, 205 (33.7%) with pT2N0, 82(13.5%) with pT3-5N0, and 116 (19.1%) with pTanyN1 were identified. Conditional CSM-free estimates increased from 75% to 87%, 66% to 70%, 53% to 86%, and 36 to 54% after three years of event-free follow-up in pT1b, pT2, pT3-4N0, and pTanyN1 patients, respectively, whereas it decreased from 87% to 79% in pT1aN0 patients. Based on multivariable analysis, patients with pT2N0 (hazard ratio [HR] 2.0 p < .01), pT3-4N0 (HR 2,7 p < .01), and pTanyN1-3 (HR 4.8 p < .01) had higher CSM than patients with pT1aN0 at baseline.
Conclusions
CS varied across stage categories in nmICC patients after surgery, and it was important in individualized clinical counseling and decision‐making for nmICC.
Ethics approval and informed consent
No ethical approval nor informed consent was required in this study due to the public-availability of the data used.
Author contributions
Xia Yan and Zhiqiang Meng were responsible for the conception and the design of this work. The data was collected and analyzed by Wang Lai. Interpretation of the data was performed by XiaYan. The paper was drafted by Xia Yan and revised by Lai Wang and Zhiqiang Meng. Xia Yan and Lai Wang contributed equally to this work. All authors agree to be accountable for all aspects of the work.
Disclosure statement
The authors declare no conflict of interest.
Data availability statement
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.