Effect of temperature and ultraviolet irradiation on free radical scavenging activity of simvastatin

Abstract

Simvastatin characterizes antioxidant, antitumor, anti-inflammatory, and anticoagulant properties. The aim of the study was to estimate free radical scavenging activity of simvastatin at different physical conditions by the use of electron paramagnetic resonance spectroscopy. Simvastatin was storage at room temperature, 37 °C, and 41 °C, and it was exposed to ultraviolet irradiation. The antioxidative character was stated for all the simvastatin samples, which quenched free radicals. The higher free radical scavenging activity revealed the heated simvastatin than that storage at room temperature. Simvastatin may be exposed to ultraviolet irradiation, but the storage temperature should not be increased. The kinetics indicates fast free radical interactions of the tested samples. Electron paramagnetic resonance spectroscopy is useful to optimization of storage conditions of simvastatin.

Keywords:

• Electron paramagnetic resonance spectroscopy
• free radicals
• simvastatin
• storage temperature
• ultraviolet irradiation

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Medical University of Silesia, Katowice, Poland (grant numbers: PCN-1-014/K/0/F, PCN-1-166-K/0/F).