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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 20
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Articles

Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies

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Pages 2683-2695 | Received 13 Apr 2019, Published online: 16 Jul 2019
 

Abstract

A facile and highly efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives has been developed by the condensation of anthranilamide with aldehydes using sulfonic acid functionalized l-Proline@Fe3O4 nanoparticles as a catalyst. The advantages of this protocol are easy recovery and reusability of the catalyst besides simple work-up procedure and short reaction time. In addition, the anthelmintic activities of some selective compounds were investigated and it was found that 2-phenyl-2,3-dihydroquinazolin-4(1H)-one exhibited profound anthelmintic activity against two helminth models.

Graphical Abstract

Acknowledgments

The authors acknowledge SAIF-NEHU, Department of chemistry, NEHU, Dr L. Robindro Singh, Department of Nanotechnology for Powder XRD data analysis. The authors also acknowledge the CIF, IIT Guwahati for VSM and FE-SEM analysis.

Additional information

Funding

The authors acknowledge the financial support from DST-SERB [sanctioned no.: EEQ/2016/000646].

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