Regioselective synthesis and biological evaluation of novel dispiropyrrolidine derivatives via one-pot four-component reaction

Abstract

A new series of regioselective dispiropyrrolidine analogs via efficient one-pot four-component tandem reaction has been discovered. The reaction was carried out in the presence of four common reactants and magnesium silicate nanoparticles (NPs) in ethanol under microwave irradiation. The reaction proceeds rapidly and can be completed within 60–90 min. This methodology offers several significant advantages such as high yield, mild catalyst, and easy to perform. The synthesized compound was further screened for antibacterial and antiproliferative activities. The results showed that compound 5c and 5a were potent antibacterials against Gram-positive and Gram-negative bacteria. Further, 5a showed best antiproliferative activity against tested cell lines.

GRAPHICAL ABSTRACT

Keywords:

• Antimicrobial
• antiproliferative
• aryl aldehydes
• microwave irradiation
• N,N-dimethyl barbituric acid
• sarcosine

Additional information

Funding

The authors express their gratitude to RFTT scheme of VGST, Govt of Karnataka, and Fast-Track scheme of DST-SERB for financial support.