One-pot B(C₆F₅)₃ catalyzed cascade synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-ones

Abstract

A new and efficient B(C₆F₅)₃ catalyzed domino strategy has been developed for the synthesis of 2-substituted quinazolinones. The reaction utilizes 2-aminobenzamide and aldehydes for a one-pot protocol. A wide range of substrate scope, functional group tolerance, and operational simplicity with excellent yield are synthetically useful features.

Graphical Abstract

Keywords:

• Aldehyde
• 2-aminobenzamide
• quinazolinone
• tris(pentafluorophenyl)borane

Acknowledgments

The authors are grateful to the Department of Postgraduate Studies and Research centre in Chemistry, Shivaji Mahavidyalay, Udgir, and Sanjeevanee Mahavidyalaya, Chapoli, India, for providing laboratory facilities and Indian Institute of Chemical Technology, Hyderabad, for spectral analysis.