Reactions of derivatives of phosphorylacetic acid hydrazides with 3,5-di-tert-butyl-4-hydroxybenzyl acetate

Abstract

To obtain new polyfunctional inhibitors of radical-chain oxidative processes, C- and N-benzylation of a number of phosphorylacetic acid hydrazide derivatives is realized in their reactions with 3,5-di-tert-butyl-4-hydroxybenzyl acetate. N-benzylation of mixtures of Z and E isomers of hydrazones of phosphorylacetic acid derivatives proceeds stereoselectively with the formation of only E_C=N isomers.

GRAPHICAL ABSTRACT

Keywords:

• Hybrid compounds
• hydrazones of phosphorylacetic acid
• molecular structure
• sterically hindered phenols
• synthesis

Acknowledgments

The study of the synthesized compounds by physical methods was carried out in the Assigned Spectral-Analytical Center of Shared Facilities for Study of Structure, Composition and Properties of Substances and Materials of Federal Research Center of Kazan Scientific Center of Russian Academy of Sciences.

Disclosure statement

No potential conflict of interest was reported.

Additional information

Funding

This work was carried out within the framework of the governmental task of the Ministry of Education and Science of the Russian Federation (no. 10.1718.2017/P4).