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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 5
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SYNTHETIC COMMUNICATIONS REVIEWS

Highly efficient and green synthesis of 2,4-diphenyl substituted thiazoles

Jungan ZhangSchool of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, P. R. China; ;Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan, P. R. China; View further author information
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Peipei LiSchool of Pharmacy, Ningxia Medical University, Yinchuan, P. R. ChinaView further author information
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Hongyun ZengSchool of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, P. R. China; ;Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan, P. R. China; View further author information
,
Yu HuangSchool of Pharmacy, Ningxia Medical University, Yinchuan, P. R. ChinaCorrespondence[email protected]
View further author information
&
Wei HongSchool of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, P. R. China; ;Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan, P. R. China; Correspondence[email protected]
View further author information
Pages 735-741 | Received 16 Dec 2019, Published online: 03 Feb 2020
 
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Abstract

2,4-Diphenyl thiazole is an important organic intermediate and its derivatives contain multiple biological properties. In the present study, we reported a new protocol to synthesize 2,4-diphenyl thiazole analogs, which involved the bromination of ethyl benzoylacetates with NBS in the presence of 2-hydroxypropyl-β-cyclodextrin, followed by a direct cyclization with thiobenzamides in water. Compared with the reported method, the current protocol contains less reaction steps, milder reaction conditions, and simpler workup procedure.

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Funding

This study was supported by the National Natural Science Foundation of China [Grant No. 81660588, 81960623]; and the Key R&D Program of Ningxia [Grant No. 2018BFG02004].

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