Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 7
273
Views
10
CrossRef citations to date
0
Altmetric
ARTICLES

ZnO nanoparticles catalyzed synthesis of bis- and poly(imidazoles) as potential anticancer agents

, , &
Pages 980-996 | Received 17 Oct 2019, Published online: 19 Feb 2020
 

Abstract

A synthesis of bis- and poly(imidazoles) by one-pot three-component reaction of 1,2-diketone with aldehydes and ammonium acetate in the presence of catalytic amount of ZnO nanocatalyst is reported. The reactions were performed under conventional heating as well as under microwave irradiation. The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF-7), liver cancer cell line (HepG-2), and epithelial colorectal adenocarcinoma cells (CaCO-2). The results of the cytotoxic activity revealed that compound 16 b with bis(imidazole) analog that incorporated a 4,5-difuran rings was potent against HepG-2 cancer cells (IC50 = 8.14 µM) with high selectivity index (SI = 27.47). Compound 25 incorporating four imidazole units was active against MCF-7 cell line (IC50 = 12.62 µM) and showed a significant selectivity index (SI = 7.71). Moreover, compound 27 containing six imidazole units exhibited the highest activity against the CaCO-2 cell line (IC50 = 32.51 μM) with SI = 4.09.

Graphical Abstract

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.