Abstract
Formal total synthesis of dihydrokawain-5-ol is accomplished starting from tartaric acid. Key reactions include Horner–Wadsworth–Emmons olefination, sodium borohydride mediated stereoselective reduction, orthogonal protection and deprotection of alcohols and ring closing metathesis.
Graphical Abstract
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Acknowledgments
P.K.M thanks the University Grants Commission (UGC), New Delhi for a senior research fellowship and also his research mentor Prof. K. R. Prasad for the encouragement and helpful discussion.