Silica chloride (SiO₂-Cl) catalyzed one pot synthesis of 2,3-disubstituted-thiazolidin-4-one

Abstract

In this paper, we report one-pot, three-component cyclo condensation of an aldehyde, an amine and thioglycolic acid to form 2,3-disubstituted-thiazolidin-4-one by using supported protic acid (Silica Chloride: SiO₂-Cl) catalyst. The catalyst SiO₂-Cl is compatible with a variety of aldehydes (aryl/heteroaryl) and the aromatic amines affording 2,3-disubstituted-thiazolidin-4-one analogs in 72–89% yields. Moreover, the supported catalyst was recycled several times without significant loss of catalytical activity

Graphical Abstract

Keywords:

• Cyclocondensation
• 2,3-disubstituted-thiazolidin-4-one
• one-pot reaction
• recycle
• supported SiO₂-Cl catalyst
• three-component

Acknowledgment

Authors would like to thank SAIF, Panjab University for recording ¹H and ¹³C NMR.