Mandelic acid catalyzed one-pot three-component synthesis of α-aminonitriles and α-aminophosphonates under solvent-free conditions at room temperature

Abstract

A simple, mild, straightforward, efficient and eco-friendly protocol has been developed for the synthesis of a series of α-aminonitriles via the one-pot three-component Strecker reactions between various aldehydes, amines and trimethylsilyl cyanide using a catalytic amount of mandelic acid as a naturally occurring, low-cost, efficient organo-catalyst under solvent-free conditions at room temperature. Under the same optimized conditions synthesis of α-aminophosphonates were also achieved via the one-pot three-component Kabachnik-Fields reactions of aldehydes, amines and triethyl phosphate.

Graphical Abstract

Keywords:

• α-Aminonitriles
• α-aminophosphonates
• mandelic acid
• room temperature
• organocatalysis

Acknowledgements

Dr. B. Banerjee is thankful to the Indus International University, Una, Himachal Pradesh, India and the Kartha Education Society, Mumbai, India for the support. Authors are grateful to AMRC, IIT Mandi, Himachal Pradesh, India for the spectral measurements such as FTIR, NMR, HRMS as well as single XRD data.

Disclosure statement

The authors declare no conflict of interest.