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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 21
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Articles

Efficient synthetic method of β-fluorocinnamate by arylboronic acids and ethyl 3,3,3-trifluoropropionate under palladium-catalyzed conditions

Wei-Hao Chena Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, P. R. ChinaView further author information
,
Xiao-Jun Peia Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, P. R. ChinaView further author information
,
Xiao-Xuan Lia Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, P. R. ChinaView further author information
&
Yi-Si Fenga Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, P. R. China;b Anhui Provincial Laboratory of Heterocyclic Chemistry, Maanshan, P. R. ChinaCorrespondence[email protected]
View further author information
Pages 3212-3220 | Received 23 Feb 2020, Published online: 30 Jul 2020
 
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Abstract

A convenient and efficient method for synthesizing β-fluorocinnamate and derivatives is reported. Palladium (II) catalysis was employed in β-F elimination and coupling reaction of phenylboronic acid and ethyl 3,3,3-trifluoropropionate with a high yield and E-selectivity. The reaction was conducted under mild conditions and could be widely adapted to boronic acid substrates.

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Acknowledgments

We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

Additional information

Funding

The present work was financially supported by Natural Science Foundation of China [21971050].

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