KI catalyzed C–H functionalization of acetone for the synthesis of 2-oxopropyl hetero-aromatic carboxylates

Abstract

KI catalyzed C–H functionalization of acetone with hetero-aromatic carboxylic acids has been developed. With potassium iodide as catalyst and sodium chlorite as oxidant, cascade reaction including α-H electrophilic substitution of acetone and nucleophilic substitution of iodoacetone occur smoothly. 2-Oxopropyl hetero-aromatic carboxylates are obtained with the good to excellent yields.

Graphical Abstract

Keywords:

• Acetone
• C–H functionalization
• catalysis
• iodide
• oxopropyl carboxylates

Additional information

Funding

The work was supported by the National Natural Science Foundation of China [Grant No. 22062012], the Foundation of Guizhou Educational Committee [Grant No. qianjiaohe KY zi [2019] 081] and the Natural Science Foundation of Guizhou Province [Grant No. qiankehejichu [2018] number 1141].