A novel and efficient four-component synthesis of chromen–based dithiocarbamate derivatives by homogeneous catalysts under solvent-free conditions

Abstract

An efficient and one-pot procedure is described for the synthesis of a variety of derivatives of 1,2-dihydrobenzo[f]chromen-3-ones and 3,4-dihydrochromen-2-ones under solvent-free conditions via a pseudo-four-component domino reaction of acetic anhydride, aryl aldehydes, glycine-based dithiocarbamates, and phenols/naphthols in the presence of l-proline and H₄[Si(W₃O₁₀)₄].xH₂O as green catalysts. All products were made under the green strategy for the synthesis of corresponding products with excellent yields (up to 94%) and diastereoselectivity.

Graphical Abstract

Keywords:

• Green reagents
• dithiocarbamates
• chromens
• l-proline
• multicomponent reaction
• tungstosilicic acid hydrate

Acknowledgments

We thank Ms. Jarahiyan for her kind collaboration at this project. We are grateful to the faculty of chemistry of the Sharif University of Technology for supporting this project.