Triethylamine-catalyzed unprecedented synthesis of 2-amino-4-phenylbenzo [4, 5] imidazo [1,2-a] pyrimidine-3-carbonitrile under solvent free condition

Abstract

An efficient and experimentally straightforward method for the synthesis of 2-amino-4-phenylbenzo [4,5] imidazo [1,2-a] pyrimidine-3-carbonitrile derivatives has been developed via one pot three-component reaction of 2-aminobenzimidazole, cyanoacetamide and aromatic aldehydes in the presence of triethylamine under solvent-free reaction condition. This green procedure offers several advantages such as high atom economy, short reaction time, metal-free and solvent-free reaction conditions, easy work up and column chromatography-free method with a wide range of functional group tolerance. This has made the protocol sustainable and economical.

Graphical Abstract

Keywords:

• Green chemistry
• multicomponent reactions (MCRs)
• one-pot reaction
• solvent-free reaction