Abstract
We report a two-step rapid and efficient synthesis of β-amino-α,β-unsaturated esters. Microwave-assisted synthesis was used throughout the process. Seventeen β-amino-α,β-unsaturated esters were produced in excellent yields and short reaction times. The effects of the heating method and substituents, especially the o-substituted group of the phenols or thiophenols, were investigated. A plausible reaction mechanism is also proposed.
Graphical Abstract
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Acknowledgment
The authors thank Zaozhuang University and Lunan Institute of Coal Chemical-engineering Technology Research.
Disclosure statement
No potential conflict of interest was reported by the author(s).