Abstract
We report an efficient synthesis of 4-aminotetrahydropyrazolo[3,4-b]quinolin-5-one derivatives via Friedländer-type reaction of dimedone with 5-aminopyrazole-4-carbonitriles in the presence of an acidic catalyst. We also report the synthesis of N-(1H-pyrazol-5-yl)- pyridine-3-carbonitrile via the reaction of pyrazol-5-ylcyanoacetamide with acetylacetone in the presence of basic catalyst.
Graphical Abstract
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