Synthesis of 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazines via tandem reactions of β-iodoazides with propargyl alcohols

Abstract

Tandem reactions between β-iodoazides and propargyl alcohols under mild conditions are presented, providing a general and convenient method for the synthesis of 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazines. The advantages of this method are its simple operation, high efficiency and high product yields (80–95%).

Graphical Abstract

Keywords:

• 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazines
• β-iodoazides
• one-pot procedure
• propargyl alcohols
• tandem reactions

Additional information

Funding

We are grateful to the National Natural Science Foundation of China (No. 21762022), the Research Program of Jiangxi Province Department of Education (No. GJJ160289, GJJ11380), the Opening Foundation of Key Laboratory of Functional Small Organic Molecule of Ministry of Education (No. KLFS-KF-201912, KLFS-KF-201928) and the Opening Foundation of Jiangxi Polymer Engineering Research Center (No. KFJJ2021005) for the financial support.