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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 21
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Articles

Synthesis and antimicrobial activity of 4-methylthiazole and 4-thiazolidinone derivatives derived from 5-(aryldiazo)salicylaldehyde thiosemicarbazones

Mohamed A. Salema Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail, Saudi Arabia;b Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, EgyptView further author information
,
Samir Y. Abbasc Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-7584-5030View further author information
ORCID Icon,
Marwa A. M. Sh. El-Shariefa Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail, Saudi Arabia;d Applied Organic Chemistry Department, National Research Centre, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0001-8516-6808View further author information
ORCID Icon,
Abdullah Y. Alzahrania Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail, Saudi ArabiaView further author information
,
Mohamed H. Helale Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi ArabiaView further author information
&
Hamdy Kh. Thabete Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi ArabiaView further author information
Pages 3325-3331 | Received 03 Jun 2021, Published online: 27 Aug 2021
 
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Abstract

New series of thiazole derivatives were synthesized using 5-(aryldiazo)salicylaldehyde thiosemicarbazones 2a–i. Cyclocondensation of thiosemicarbazones 2a–i with chloroacetone afforded the corresponding 4-methylthiazole derivatives 3a–i. Moreover, cycloalkylation of 2a–i with ethyl bromoacetate afforded the corresponding thiazolidin-4-one derivatives 4a–i. The antimicrobial activity of the new thiazole derivatives was evaluated.

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Funding

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through General Research Project under grant number (RGP. 2/88/42).

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