The synthesis of phenyl carbamates catalyzed by iron (II) bromide: An oxidative approach for cross-coupling of phenols with formamides

Abstract

The carbamate group is a key structural motif in many approved drugs and pro-drugs. There is increasing use of carbamates in the medicinal chemistry and agrochemical industry. We present, reagents and chemical methodologies for the synthesis of carbamates, and recent applications. The direct coupling of simple phenols with mono- and di-alkyl formamides provided the phenylcarbamate products.

Graphical Abstract

Keywords:

• CDC reaction
• formamide
• iron (II) bromide
• oxidation
• 1
• 10-phenanthroline
• phenyl carbamate

Acknowledgements

We thank Department of Chemistry, GITAM Deemed to be University, Hyderabad Campus, India, for providing space and instrumental support.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

GITAM Deemed to be University.