β-cyclodextrin: Green catalyst for the efficient and expeditious synthesis of benzodiazepines under aqueous conditions

Abstract

An efficient and facile green method for synthesis of four substituted 1,5-benzodiazepine derivatives via a three-component reaction of dimedone, o-phenyl diamine, and various substituted aldehydes are designed using β-cyclodextrin as a catalyst at reflux condition. The current one-pot multicomponent methodology offers several advantages, such as good to excellent yields, simplicity in experimental procedure, easy work-up procedure, shorter reaction time, energy-conserving, broad substrate scope, avoidance of hazardous chemicals, etc. Further, the catalyst was recovered and recycled 4–5 times without compromising the yield of the final product.

Graphical Abstract

Keywords:

• Benzodiazepines
• β-cyclodextrin
• green solvent
• multicomponent reactions (MCR)

Acknowledgments

The author LBM is thankful to ADF (AICTE) for awarding the fellowship, and PKB is thankful to DST for awarding the INSPIRE fellowship.

Disclosure statement

No potential conflict of interest was reported by the author(s).