Abstract
2,2’-dipyridylamine (DPA) is hereby firstly reported as a novel and efficient tridentate ligand for promoting copper(I)-catalyzed C-O/S coupling reactions of abundant aryl bromines with related phenols or thiophenols. The key to this very discovery is the identification of an N-donor tripod ligand (DPA), and such a reaction allows the conversion of simple starting materials to complex diaryl ethers or diaryl thioethers, which are important synthetic intermediates in the preparation of bioactive molecules.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.