Synthesis of the C/D/E-ring core compound of maoecrystal V

Abstract

Maoecrystal V is a highly oxidized and rearranged norterpenoid isolated from the Chinese herb, Isodon eriocalyx. A synthetic route for the C/D/E-ring core compound of maoecrystal V has been developed. Introduction of the C1 fragment to the D/E-ring compound was achieved by lithito dithiane attack, and the C-ring was formed by deprotective intramolecular hemiacetalization of the dithiane-alcohol precursor.

GRAPHICAL ABSTRACT

Keywords:

• Deprotective acetal formation
• 1,3-dithiane
• maoecrystal V
• norterpenoids
• synthesis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the JSPS KAKENHI under Grant Nos. 17580092, 19580120, 22560112, 25450144, and 17K07772.