Abstract
Immunomodulators are assigned as a robust tool for the treatment of various medical conditions like AIDS, cancer and autoimmune diseases. In this work, we have synthesized a series of fluoxetine-based small-molecule immunomodulators. Molecules were synthesized by a convergent strategy, where mitsunobu reaction was conducted to synthesize the common starting material. The novel analogues displayed immunomodulatory potential as indicated by the anti-inflammatory effect derived through the compound’s T cell proliferation inhibitory property. The synthesized novel analogues manifested encouraging biological responses, assure their application as immunomodulators.
GRAPHICAL ABSTRACT
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Acknowledgements
MNT thanks ICMR for the award of Senior Research fellowships (GAP-0806). The authors are very thankful to DBT for funding the research under the budget head GAP 0803. IICT communication number-IICT/Pubs./2022/222. Note: The above work has been filed for patent with title “Synthesis and Biological evaluation of Novel 3-phenyl-3-(aryloxy) propan-1-amines and the process for the preparation thereof” Filing No: 202211060662, Dated: Oct/2022.
Disclosure statement
No potential conflict of interest was reported by the author(s).