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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 53, 2023 - Issue 13
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Synthetic Communications Reviews

β-Enaminones from cyclohexane-1,3-diones: Versatile precursors for nitrogen and oxygen-containing heterocycles synthesis

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Pages 953-993 | Received 23 Jan 2023, Published online: 21 Apr 2023
 

Abstract

β-Enaminones derived from cyclohexane-1,3-diones reveal a vast variety of bioactivities including anticonvulsant, anti-inflammatory, analgesic, etc. Further, these β-Enaminones are versatile precursors for the synthesis of several other important heterocycles that illustrates antimicrobial, antibacterial, antifungal, antitumor, calcium channel antagonist, cardiovascular, antiviral activities, etc. Recently, reactions of various β-enaminones with their counterpart for example aldehydes, Meldrum’s acid, N-arylitaconimides, malononitriles, cyanoacetamide, arylglyoxals, ortho-hydroxybenzyl alcohols, o-hydroxystyrenes, and acenaphthoquinone have been recognized for the synthesis of different nitrogen and oxygen heterocycles involving 2-quinolone, 1,4-dihydropyridine, acridine-1,8-dione, indoles, xanthenes, chromenones, etc. These significances of β-enaminones enthused us to assemble all newly developed methods for the creation of important nitrogen and oxygen-containing heterocycles, which are the chief attraction of this review article.

Graphical Abstract

Acknowledgments

D. S. would like to acknowledge the support of the Principal, Jagdish Chandra DAV College, Dasuya, Dist. Hoshiarpur, Punjab, India-144205. M. K. has a special thanks to the Principal Swami Vivekanand Govt College Ghumarwin, HP, India; S. K. especially thanks to the vice-chancellor of Lovely Professional University, Phagwara, for providing basic amenities during the work. P. D. is grateful to the Director of CSIR-IHBT for providing the necessary facilities during this work.

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