Design, fabrication, in vivo and in vitro characterizations of novel PLGA thread-embedding materials for juvenile pseudo-myopia

Abstract

Polylactic-co-glycolic acid (PLGA) acupoint catgut-embedding (ACE) multifilament was braided into thread structure, in vivo and in vivo performances were fully investigated. These findings indicated that samples had the relatively intact structures in the first 4 weeks, and their weights lost more than 80% in the 10 weeks. With the further degradation, mechanical properties became worse, a sharp decrease was observed in the 6 weeks. Samples presented more than 75% of cells being viable, and the surrounding tissues of samples grew well according to Hematoxylin and eosin (H&E) staining measurement. In sum, these findings warrant further study on PLGA embedding materials with outstanding clinical efficacy.

Keywords:

• Polylactic-co-glycolic acid (PLGA)
• acupoint catgut-embedding (ACE)
• cell viability
• histological evaluation

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work is sponsored by Shanghai Sailing Program (20YF1401000), the Fundamental Research Funds for the Central Universities (2232020D-17), the Initial Research Funds for Young Teachers of Donghua University, and “111 Project” - Biomedical Textile Materials Science and Technology (B07024). The first author thanks the scholarship support from China Scholarship Council (CSC).