Dynamic behavior of nanofibrous bioscaffolds

Abstract

Given that the mechanical forces acted on bioscaffolds affect the adhesion, proliferation, and migration of the cells within them, the study of their mechanical properties is considered as important. Mechanical forces on cell depend on the properties of bioscaffolds, which the characteristics are a function of their microstructure. The present study assesses the correlation between the microstructure and dynamic behavior of the nanofibrous mats produced at different electrospinning voltage and polymer molecular weight. Additionally, fiber diameter, cell size, and cell number of mats are estimated based on their density and BET adsorption data. The dynamic behavior of bioscaffolds was evaluated through employing dynamic mechanical analysis in temperature and frequency sweep modes. The results revealed that a reduction in fiber diameter elevated their number, and consequently enhanced cell count and decreased cell size. Further, a raise in molecular weight resulted in increasing the storage and loss modulus of scaffolds, and electrospinning voltage influenced the mechanical properties. Finally, the dynamic and mechanical properties of scaffold can be controlled by modifying its microstructure.

Keywords:

• Bioscaffold
• dynamic behavior
• electrospinning
• microstructure
• molecular weight

Disclosure statement

No potential conflict of interest was reported by the author(s)