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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 10
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration

, , , &
Pages 1236-1241 | Received 27 Feb 2020, Accepted 22 Mar 2020, Published online: 06 Apr 2020
 

Abstract

  1. Plasma pharmacokinetics (PK) and tissue disposition of enrofloxacin (EFX) was studied in rainbow trout (Oncorhynchus mykiss) after a single oral administration of 10 mg/kg, and by immersion baths of 20 ppm during 2.5 h and 100 ppm during 0.5 h, at water temperature of 16.3 ± 0.3 °C.

  2. Concentrations of EFX in plasma and tissues (skin, muscle, liver, kidney and gut) were determined using high performance liquid chromatography (HPLC) with fluorescence detection.

  3. Pharmacokinetic parameters were analyzed with a non-compartmental model. After oral administration, t½β, AUC and AUCtissues/AUCplasma ratio were 42.98 h, 21.80μg-h/ml and ≤ 18.63, respectively.

  4. After immersion baths of 20 ppm during 2.5 h and 100 ppm during 0.5 h, the t½β, AUC and AUCtissues/AUCplasma were 42.77 and 44.67, 9.83 and 12.83 μg-h/ml and ≤ 9.81 and ≤ 7.13, respectively.

  5. Therefore, oral (10 mg/kg) and bath administration in rainbow trout can provide AUC/MIC of ≥125 and Cmax/MIC of ≥10 to treat diseases caused by susceptible bacteria with MIC ≤ 0.04 μg/ml. This information can be helpful for the right use of EFX in rainbow trout. Also, this is the first study that determines the antibiotic tissue disposition in rainbow trout by using different administration routes.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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