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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 9
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Meeting Report

Meeting report of the first European biotransformation workshop

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Pages 1081-1086 | Received 09 Jul 2021, Accepted 16 Jul 2021, Published online: 29 Jul 2021
 

Abstract

1. Challenges and opportunities in the field of biotransformation were presented and discussed at the 1st European Biotransformation workshop which was conducted virtually in collaboration with the DMDG 27 January 2021. Here we summarize the presentations and discussions from this workshop.

The following topics were covered:

  • 2. Needs for radiolabel for IND filing versus quantitation without standards.

  • 3. Applications of cyclic ion mobility in the field of biotransformation.

  • 4. Computational predictions of xenobiotic metabolism.

  • 5. Future (outsourcing) needs in biotransformation.

  • 6. Genotoxicity risk assessment of metabolites and qualification of impurities using metabolite data.

  • 7. Regulatory aspects of MIST.

Acknowledgements

The organizers would like to extend their gratitude to all presenters (Johannes Kirchmair, David Higton, Sekhar Surapaneni, Andreas Zeller, Andreas Brink, Alexander David James), to all additional moderators (Christian Lanshoeft, Claude Delatour) and to all participants for fruitful discussions. We would like to acknowledge also the DMDG organizing and technical team, in particular Stuart Hex and Chris Barron (AssociAction Enterprises). Without their support, this virtual event would have not been possible. At last, we would like to also express our gratitude to Jesper Kammersgaard.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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