ABSTRACT
Objective: The objective of the study is to examine the association between physical activity and hippocampal–orbitofrontal functional connectivity.
Methods: Data from the Nathan Kline Institute-Rockland Sample was utilized, which consisted of 366 participants (Mage = 43 years; 63% female). Physical activity was self-reported using the International Physical Activity Questionnaire. Hippocampal–orbitofrontal functional connectivity was assessed from magnetic resonance imaging.
Results: Moderate-intensity physical activity was not statistically significantly associated with left hippocampal–orbitofrontal connectivity (β = 0.001; 95% CI: −0.02, 0.03; P = 0.90) or right hippocampal–orbitofrontal connectivity (β = 0.01; 95% CI: −0.01, 0.04; P = 0.22). However, vigorous-intensity physical activity was statistically significantly associated with right hippocampal–orbitofrontal connectivity (β = 0.01; 95% CI: 0.004, 0.02; P = 0.002).
Discussion: Habitual engagement in intense physical activity was associated with greater hippocampal–orbitofrontal connectivity, while moderate activity engagement was not. This may have important implications for the exercise neurobiology field in the context of exercise and memory function, suggesting that intense activity may facilitate cognitive/memory functions. However, our findings should be interpreted with caution given the relatively weak associations that were observed.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Peer reviewers on this manuscript have no relevant financial relationships to disclose.